Authors
Michael S Saag, Constance A Benson, Rajesh T Gandhi, Jennifer F Hoy, Raphael J Landovitz, Michael J Mugavero, Paul E Sax, Davey M Smith, Melanie A Thompson, Susan P Buchbinder, Carlos del Rio, Joseph J Eron, Gerd Fätkenheuer, Huldrych F Günthard, Jean-Michel Molina, Donna M Jacobsen, Paul A Volberding
Publication date
2018/7/24
Journal
JAMA
Volume
320
Issue
4
Pages
379-396
Publisher
American Medical Association
Description
Importance
Antiretroviral therapy (ART) is the cornerstone of prevention and management of HIV infection.
Objective
To evaluate new data and treatments and incorporate this information into updated recommendations for initiating therapy, monitoring individuals starting therapy, changing regimens, and preventing HIV infection for individuals at risk.
Evidence Review
New evidence collected since the International Antiviral Society–USA 2016 recommendations via monthly PubMed and EMBASE literature searches up to April 2018; data presented at peer-reviewed scientific conferences. A volunteer panel of experts in HIV research and patient care considered these data and updated previous recommendations.
Findings
ART is recommended for virtually all HIV-infected individuals, as soon as possible after HIV diagnosis. Immediate initiation (eg, rapid start), if clinically appropriate, requires adequate staffing …
Scholar articles
MS Saag, CA Benson, RT Gandhi, JF Hoy… - Jama, 2018