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Antimicrobial resistance (AMR) is among the leading global public health threats of the 21st century. Thus, AMR threatens human, animal, and environmental health globally (Abia and Essack, 2023). Moreover, the widespread misuse and uncontrolled prescription of antibiotics aggravates the problem, diminishing antibiotic efficacy, including last-resort ones (Lu et al., 2023). This problem is accentuated in rural settings in low-and middleincome countries where community members are small-scale farmers, often living with their livestock inside the yards and lacking adequate water and sanitation facilities (Sulis et al., 2022). Inadequate animal and human waste disposal from household and agricultural practices could transfer antimicrobial-resistant pathogens and their associated genes to the environment. These pollutants may pose a health risk to resource-limited community members upon exposure to such polluted environments. Therefore, monitoring antimicrobial resistance requires a one health approach involving the human, animal, and environmental sectors. Furthermore, employing advanced genomic tools to complement existing culture-based techniques would provide a more comprehensive appreciation of the extent of AMR globally. Therefore, the current Research Topic aimed at providing an update on the one health approach to AMR using cultural and genomic approaches. This Research Topic includes seven articles by 45 authors from eight countries in the Americas, Asia, and Europe.

The development of resistance in bacteria is a complex process involving several mechanisms. Ramamurthy et al. reviewed the genetic network …