Authors
Lloyd Paul Aiello, Robert L Avery, Paul G Arrigg, Bruce A Keyt, Henry D Jampel, Sabera T Shah, Louis R Pasquale, Hagen Thieme, Mami A Iwamoto, John E Park, Hung V Nguyen, Lloyd M Aiello, Napoleone Ferrara, George L King
Publication date
1994/12/1
Journal
New England Journal of Medicine
Volume
331
Issue
22
Pages
1480-1487
Publisher
Massachusetts Medical Society
Description
Background
Retinal ischemia induces intraocular neovascularization, which often leads to glaucoma, vitreous hemorrhage, and retinal detachment, presumably by stimulating the release of angiogenic molecules. Vascular endothelial growth factor (VEGF) is an endothelial-cell-specific angiogenic factor whose production is increased by hypoxia.
Methods
We measured the concentration of VEGF in 210 specimens of ocular fluid obtained from 164 patients undergoing intraocular surgery, using both radioimmunoassays and radioreceptor assays. Vitreous proliferative potential was measured with in vitro assays of the growth of retinal endothelial cells and with VEGF-neutralizing antibody.
Results
VEGF was detected in 69 of 136 ocular-fluid samples from patients with diabetic retinopathy, 29 of 38 samples from patients with neovascularization of the iris, and 3 of 4 samples from patients with ischemic occlusion of …
Total citations
Scholar articles
LP Aiello, RL Avery, PG Arrigg, BA Keyt, HD Jampel… - New England Journal of Medicine, 1994