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Bulk-rock major and trace element, Sr–Nd isotope, zircon U–Pb and Hf-isotope data are reported for Early Cretaceous igneous rocks sampled along an east–west traverse through the central Lhasa subterrane (E80°00′–E89°) in southern Tibet. These results offer new insights into the pre-Cenozoic geology and tectonomagmatic evolution of the Lhasa Terrane, and provide boundary conditions for the origin and evolution of the Tibetan Plateau. Our new data, together with data from the literature indicate that the Early Cretaceous magmatism in the central Lhasa subterrane lasted for a long period (~143–102Ma) with a magmatic flare-up at ~110 Ma. The latter is accompanied by mafic magmatism in this terrane. The silicic rocks are metaluminous to peraluminous, and enriched in Rb, Th, and U, and depleted in Ba, Nb, Ta, Sr, P, and Ti, with varying initial ⁸⁷Sr/⁸⁶Sr (0.7073–0.7209), negative ε_Nd(t) (−13.7 to −4.6 …