Authors
Dongmei Yu, Jae Hoon Sul, Fotis Tsetsos, Muhammad S Nawaz, Alden Y Huang, Ivette Zelaya, Cornelia Illmann, Lisa Osiecki, Sabrina M Darrow, Matthew E Hirschtritt, Erica Greenberg, Kirsten R Muller-Vahl, Manfred Stuhrmann, Yves Dion, Guy Rouleau, Harald Aschauer, Mara Stamenkovic, Monika Schlögelhofer, Paul Sandor, Cathy L Barr, Marco Grados, Harvey S Singer, Markus M Nöthen, Johannes Hebebrand, Anke Hinney, Robert A King, Thomas V Fernandez, Csaba Barta, Zsanett Tarnok, Peter Nagy, Christel Depienne, Yulia Worbe, Andreas Hartmann, Cathy L Budman, Renata Rizzo, Gholson J Lyon, William M McMahon, James R Batterson, Danielle C Cath, Irene A Malaty, Michael S Okun, Cheston Berlin, Douglas W Woods, Paul C Lee, Joseph Jankovic, Mary M Robertson, Donald L Gilbert, Lawrence W Brown, Barbara J Coffey, Andrea Dietrich, Pieter J Hoekstra, Samuel Kuperman, Samuel H Zinner, Pétur Luðvigsson, Evald Sæmundsen, Ólafur Thorarensen, Gil Atzmon, Nir Barzilai, Michael Wagner, Rainald Moessner, Roel Ophoff, Carlos N Pato, Michele T Pato, James A Knowles, Joshua L Roffman, Jordan W Smoller, Randy L Buckner, A Jeremy Willsey, Jay A Tischfield, Gary A Heiman, Hreinn Stefansson, Kári Stefansson, Danielle Posthuma, Nancy J Cox, David L Pauls, Nelson B Freimer, Benjamin M Neale, Lea K Davis, Peristera Paschou, Giovanni Coppola, Carol A Mathews, Jeremiah M Scharf, Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group
Publication date
2019/3/1
Journal
American Journal of Psychiatry
Volume
176
Issue
3
Pages
217-227
Publisher
American Psychiatric Association
Description
Objective
Tourette’s syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette’s syndrome and other tic disorders. The authors conducted a GWAS meta-analysis and probed aggregated Tourette’s syndrome polygenic risk to test whether Tourette’s and related tic disorders have an underlying shared genetic etiology and whether Tourette’s polygenic risk scores correlate with worst-ever tic severity and may represent a potential predictor of disease severity.
Methods
GWAS meta-analysis, gene-based association, and genetic enrichment analyses were conducted in 4,819 Tourette’s syndrome case subjects and 9,488 control subjects. Replication of top loci was conducted in an independent population-based sample (706 case subjects, 6,068 control subjects). Relationships between Tourette’s …
Scholar articles
D Yu, JH Sul, F Tsetsos, MS Nawaz, AY Huang… - American Journal of Psychiatry, 2019