Authors
Yanjing Guo, Meng Zhao, Tao Bo, Shizhan Ma, Zhongshang Yuan, Wenbin Chen, Zhao He, Xu Hou, Jun Liu, Zhenhai Zhang, Qiang Zhu, Qiangxiu Wang, Xiaoyan Lin, Zhongli Yang, Min Cui, Lu Liu, Yujie Li, Chunxiao Yu, Xiaoyi Qi, Qian Wang, Haiqing Zhang, Qingbo Guan, Lifang Zhao, Shimeng Xuan, Huili Yan, Yanliang Lin, Li Wang, Qihang Li, Yongfeng Song, Ling Gao, Jiajun Zhao
Publication date
2019/2
Journal
Cell research
Volume
29
Issue
2
Pages
151-166
Publisher
Nature Publishing Group UK
Description
Menopause is associated with dyslipidemia and an increased risk of cardio-cerebrovascular disease. The classic view assumes that the underlying mechanism of dyslipidemia is attributed to an insufficiency of estrogen. In addition to a decrease in estrogen, circulating follicle-stimulating hormone (FSH) levels become elevated at menopause. In this study, we find that blocking FSH reduces serum cholesterol via inhibiting hepatic cholesterol biosynthesis. First, epidemiological results show that the serum FSH levels are positively correlated with the serum total cholesterol levels, even after adjustment by considering the effects of serum estrogen. In addition, the prevalence of hypercholesterolemia is significantly higher in peri-menopausal women than that in pre-menopausal women. Furthermore, we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX …
Scholar articles
Y Guo, M Zhao, T Bo, S Ma, Z Yuan, W Chen, Z He… - Cell research, 2019