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COVID-19 prognostication scores are all based on COVID-19 first wave, requiring prospective validation in the evolving pandemic due to SARS-CoV-2 variants (prevalent B.1.1.7 replacing parent D614) and healthcare responses altering patient demographic and mortality. Accelerated COVID-19 virtual hospital (VH) telemedicine model implementation avoids hospital admission, appropriately allocating hospital resources to pandemic needs in tandem with resumption of regular healthcare services, requires a safe triage tool. Widely used COVID-19 first wave derived prognostication scores, SOARS and 4C Mortality Score, with uncertain performance in the evolving pandemic, raises the need for prospective validation. We prospectively validate SOARS and 4C Mortality Score in the evolving UK COVID-19 second wave determining relevance for mortality and safe early discharge.