Authors
Luca Stefanucci, Camous Moslemi, Ana R Tomé, Samuel Virtue, Guillaume Bidault, Nicholas S Gleadall, Laura PE Watson, Jing E Kwa, Frances Burden, Samantha Farrow, Karina Banasik, Jakob Bay, Jens Kjærgaard Boldsen, Thorsten Brodersen, Søren Brunak, Kristoffer Burgdorf, Mona Ameri Chalmer, Maria Didriksen, Khoa Manh Dinh, Joseph Dowsett, Christian Erikstrup, Bjarke Feenstra, Frank Geller, Daniel Gudbjartsson, Thomas Folkmann Hansen, Lotte Hindhede, Henrik Hjalgrim, Rikke Louise Jacobsen, Gregor Jemec, Bitten Aagaard Jensen, Katrine Kaspersen, Bertram Dalskov Kjerulff, Lisette Kogelman, Margit Anita Hørup Larsen, Ioannis Louloudis, Agnete Lundgaard, Christina Mikkelsen, Ioanna Nissen, Mette Nyegaard, Sisse Rye Ostrowski, Ole Birger Pedersen, Alexander Pil Henriksen, Palle Duun Rohde, Klaus Rostgaard, Michael Schwinn, Kari Stefansson, Hreinn Stefánsson, Erik Sørensen, Lise Wegner Thørner, Mie Topholm Bruun, Henrik Ullum, Thomas Werge, David Westergaard, Ji Chen, Cassandra N Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J Corbin, Jian’an Luan, Sara M Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud S Boutin, Reedik Mägi, Johannes Waage, Ruifang Li-Gao, Kei Hang Katie Chan, Jie Yao, Mila D Anasanti, Audrey Y Chu, Annique Claringbould, Jani Heikkinen, Jaeyoung Hong, Jouke-Jan Hottenga, Shaofeng Huo, Marika A Kaakinen, Tin Louie, Winfried März, Hortensia Moreno-Macias, Anne Ndungu, Sarah C Nelson, Ilja M Nolte, Kari E North, Chelsea K Raulerson, Debashree Ray, Rebecca Rohde, Denis Rybin, Claudia Schurmann, Xueling Sim, Loz Southam, Isobel D Stewart, Carol A Wang, Yujie Wang, Peitao Wu, Weihua Zhang, Tarunveer S Ahluwalia, Emil VR Appel, Lawrence F Bielak, Jennifer A Brody, Noël P Burtt, Claudia P Cabrera, Brian E Cade, Jin Fang Chai, Xiaoran Chai, Li-Ching Chang, Chien-Hsiun Chen, Brian H Chen, Kumaraswamy Naidu Chitrala, Yen-Feng Chiu, Hugoline G de Haan, Graciela E Delgado, Ayse Demirkan, Qing Duan, Jorgen Engmann, Segun A Fatumo, Javier Gayán, Franco Giulianini, Jung Ho Gong, Stefan Gustafsson, Yang Hai, Fernando P Hartwig, Jing He, Yoriko Heianza, Tao Huang, Alicia Huerta-Chagoya, Mi Yeong Hwang, Richard A Jensen, Takahisa Kawaguchi, Katherine A Kentistou, Young Jin Kim, Marcus E Kleber, Ishminder K Kooner, Shuiqing Lai, Leslie A Lange, Carl D Langefeld, Marie Lauzon, Man Li, Symen Ligthart, Jun Liu, Marie Loh, Jirong Long, Valeriya Lyssenko, Massimo Mangino, Carola Marzi, May E Montasser, Abhishek Nag, Masahiro Nakatochi, Damia Noce, Raymond Noordam
Publication date
2024/6/20
Journal
Med
Publisher
Elsevier
Description
Background
Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due to the associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing to an interplay of lifestyle, environmental, and genetic factors. Obesity has a polygenic genetic architecture; however, single genetic variants with large effect size are etiological in a minority of cases. These variants allowed the discovery of novel genes and biology relevant to weight regulation and ultimately led to the development of novel specific treatments.
Methods
We used a case-control approach to determine metabolic differences between individuals homozygous for a loss-of-function genetic variant in the small integral membrane protein 1 (SMIM1) and the general population, leveraging data from five cohorts …
Scholar articles
L Stefanucci, C Moslemi, AR Tomé, S Virtue, G Bidault… - Med, 2024