Authors
Weihua Meng, Brian W Chan, Cameron Harris, Maxim B Freidin, Harry L Hebert, Mark J Adams, Archie Campbell, Caroline Hayward, Hua Zheng, Xianwei Zhang, Lesley A Colvin, Tim G Hales, Colin NA Palmer, Frances MK Williams, Andrew McIntosh, Blair H Smith
Publication date
2020/4/15
Journal
Human molecular genetics
Volume
29
Issue
8
Pages
1396-1404
Publisher
Oxford University Press
Description
Background
Common types of musculoskeletal conditions include pain in the neck and shoulder areas. This study seeks to identify the genetic variants associated with neck or shoulder pain based on a genome-wide association approach using 203 309 subjects from the UK Biobank cohort and look for replication evidence from the Generation Scotland: Scottish Family Health Study (GS:SFHS) and TwinsUK.
Methods
A genome-wide association study was performed adjusting for age, sex, BMI and nine population principal components. Significant and independent genetic variants were then sent to GS:SFHS and TwinsUK for replication.
Results
We identified three genetic loci that were associated with neck or shoulder pain in the UK Biobank samples. The most significant locus was in an intergenic region in chromosome 17, rs12453010, having P = 1 …
Scholar articles
W Meng, BW Chan, C Harris, MB Freidin, HL Hebert… - Human molecular genetics, 2020