Authors
Liming Nie, Xin Cai, Konstantin Maslov, Alejandro Garcia-Uribe, Mark A Anastasio, Lihong V Wang
Publication date
2012/11/1
Journal
Journal of biomedical optics
Volume
17
Issue
11
Pages
110506-110506
Publisher
Society of Photo-Optical Instrumentation Engineers
Description
Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.
Total citations
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Scholar articles
L Nie, X Cai, K Maslov, A Garcia-Uribe, MA Anastasio… - Journal of biomedical optics, 2012