Authors
Chao Huang, Liming Nie, Robert W Schoonover, Zijian Guo, Carsten O Schirra, Mark A Anastasio, Lihong V Wang
Publication date
2012/6/1
Journal
Journal of biomedical optics
Volume
17
Issue
6
Pages
066016-066016
Publisher
Society of Photo-Optical Instrumentation Engineers
Description
A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.
Scholar articles
C Huang, L Nie, RW Schoonover, Z Guo, CO Schirra… - Journal of biomedical optics, 2012