Authors
Barry A Borlaug, Kevin J Anstrom, Gregory D Lewis, Sanjiv J Shah, James A Levine, Gabe A Koepp, Michael M Givertz, G Michael Felker, Martin M LeWinter, Douglas L Mann, Kenneth B Margulies, Andrew L Smith, WH Wilson Tang, David J Whellan, Horng H Chen, Victor G Davila-Roman, Steven McNulty, Patrice Desvigne-Nickens, Adrian F Hernandez, Eugene Braunwald, Margaret M Redfield
Publication date
2018/11/6
Journal
Jama
Volume
320
Issue
17
Pages
1764-1773
Publisher
American Medical Association
Description
Importance
There are few effective treatments for heart failure with preserved ejection fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has been shown to enhance nitric oxide signaling, which may improve aerobic capacity in HFpEF.
Objective
To determine the effect of 4 weeks’ administration of inhaled, nebulized inorganic nitrite on exercise capacity in HFpEF.
Design, Setting, and Participants
Multicenter, double-blind, placebo-controlled, 2-treatment, crossover trial of 105 patients with HFpEF. Participants were enrolled from July 22, 2016, to September 12, 2017, at 17 US sites, with final date of follow-up of January 2, 2018.
Interventions
Inorganic nitrite or placebo administered via micronebulizer device. During each 6-week phase of the crossover study, participants received no study drug for 2 weeks (baseline/washout) followed by study drug (nitrite or placebo) at 46 mg 3 times a …
Scholar articles
BA Borlaug, KJ Anstrom, GD Lewis, SJ Shah… - Jama, 2018