Authors
Nicholas J Ashbolt, Alejandro Amézquita, Thomas Backhaus, Peter Borriello, Kristian K Brandt, Peter Collignon, Anja Coors, Rita Finley, William H Gaze, Thomas Heberer, John R Lawrence, DG Joakim Larsson, Scott A McEwen, James J Ryan, Jens Schönfeld, Peter Silley, Jason R Snape, Christel Van den Eede, Edward Topp
Publication date
2013/9
Source
Environmental health perspectives
Volume
121
Issue
9
Pages
993-1001
Publisher
National Institute of Environmental Health Sciences
Description
Background: Only recently has the environment been clearly implicated in the risk of antibiotic resistance to clinical outcome, but to date there have been few documented approaches to formally assess these risks.
Objective: We examined possible approaches and sought to identify research needs to enable human health risk assessments (HHRA) that focus on the role of the environment in the failure of antibiotic treatment caused by antibiotic-resistant pathogens.
Methods: The authors participated in a workshop held 4–8 March 2012 in Québec, Canada, to define the scope and objectives of an environmental assessment of antibiotic-resistance risks to human health. We focused on key elements of environmental-resistance-development “hot spots,” exposure assessment (unrelated to food), and dose response to characterize risks that may improve antibiotic-resistance management options.
Discussion: Various …
Scholar articles
NJ Ashbolt, A Amézquita, T Backhaus, P Borriello… - Environmental health perspectives, 2013