Authors
Harvey O Coxson, Asger Dirksen, Lisa D Edwards, Julie C Yates, Alvar Agusti, Per Bakke, Peter MA Calverley, Bartolome Celli, Courtney Crim, Annelyse Duvoix, Paola Nasute Fauerbach, David A Lomas, William MacNee, Ruth J Mayer, Bruce E Miller, Nestor L Müller, Stephen I Rennard, Edwin K Silverman, Ruth Tal-Singer, Emiel FM Wouters, Jørgen Vestbo, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators
Publication date
2013/4/1
Journal
The lancet Respiratory medicine
Volume
1
Issue
2
Pages
129-136
Publisher
Elsevier
Description
Background
Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.
Methods
We used a random coefficient model to assess predictors of both CT lung density and its longitudinal change over 3 years in 1928 patients with COPD enrolled in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study. Lung density was measured for every voxel in the CT scan and after correcting for lung volume was expressed as the density at lowest 15th percentile point of the distribution. This study is registered with …
Scholar articles
HO Coxson, A Dirksen, LD Edwards, JC Yates… - The lancet Respiratory medicine, 2013