Authors
Gilles Lajoie, Anna Crivici, J Gordon Adamson
Publication date
1990
Journal
Synthesis
Volume
1990
Issue
07
Pages
571-572
Publisher
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Description
N-(9-Fluorenylmethoxycarbonyl) aspartic acid β-tert-butyl ester (3b)[Fmoc-Asp (OBu-t)] and N-(9-fluorenylmethoxycarbonyl)-glutamic acid γ-tert-butyl ester (4b)[Fmoc-Glu (OBu-t)] were prepared from aspartic and glutamic acids by treatment with isobutene and 4-toluenesulfonic acid followed by Fmocsuccinimide in a novel two-step, one-pot procedure to give the title compounds in moderate yield. The major byproduct of the reaction is the corresponding α-tert-butyl ester, which can be easily separated and purified.
Total citations
Scholar articles
G Lajoie, A Crivici, JG Adamson - Synthesis, 1990