Authors
Fyezah Jehan, Sunil Sazawal, Abdullah H Baqui, Muhammad Imran Nisar, Usha Dhingra, Rasheda Khanam, Muhammad Ilyas, Arup Dutta, Dipak K Mitra, Usma Mehmood, Saikat Deb, Arif Mahmud, Aneeta Hotwani, Said Mohammed Ali, Sayedur Rahman, Ambreen Nizar, Shaali Makame Ame, Mamun Ibne Moin, Sajid Muhammad, Aishwarya Chauhan, Nazma Begum, Waqasuddin Khan, Sayan Das, Salahuddin Ahmed, Tarik Hasan, Javairia Khalid, Syed Jafar Raza Rizvi, Mohammed Hamad Juma, Nabidul Haque Chowdhury, Furqan Kabir, Fahad Aftab, Abdul Quaiyum, Alexander Manu, Sachiyo Yoshida, Rajiv Bahl, Anisur Rahman, Jesmin Pervin, Jennifer Winston, Patrick Musonda, Jeffrey SA Stringer, James A Litch, Mohammad Sajjad Ghaemi, Mira N Moufarrej, Kévin Contrepois, Songjie Chen, Ina A Stelzer, Natalie Stanley, Alan L Chang, Ghaith Bany Hammad, Ronald J Wong, Candace Liu, Cecele C Quaintance, Anthony Culos, Camilo Espinosa, Maria Xenochristou, Martin Becker, Ramin Fallahzadeh, Edward Ganio, Amy S Tsai, Dyani Gaudilliere, Eileen S Tsai, Xiaoyuan Han, Kazuo Ando, Martha Tingle, Ivana Marić, Paul H Wise, Virginia D Winn, Maurice L Druzin, Ronald S Gibbs, Gary L Darmstadt, Jeffrey C Murray, Gary M Shaw, David K Stevenson, Michael P Snyder, Stephen R Quake, Martin S Angst, Brice Gaudilliere, Nima Aghaeepour
Publication date
2020/12/1
Journal
JAMA network open
Volume
3
Issue
12
Pages
e2029655-e2029655
Publisher
American Medical Association
Description
Importance
Worldwide, preterm birth (PTB) is the single largest cause of deaths in the perinatal and neonatal period and is associated with increased morbidity in young children. The cause of PTB is multifactorial, and the development of generalizable biological models may enable early detection and guide therapeutic studies.
Objective
To investigate the ability of transcriptomics and proteomics profiling of plasma and metabolomics analysis of urine to identify early biological measurements associated with PTB.
Design, Setting, and Participants
This diagnostic/prognostic study analyzed plasma and urine samples collected from May 2014 to June 2017 from pregnant women in 5 biorepository cohorts in low- and middle-income countries (LMICs; ie, Matlab, Bangladesh; Lusaka, Zambia; Sylhet, Bangladesh; Karachi, Pakistan; and Pemba, Tanzania). These cohorts were established to study maternal and fetal outcomes …
Total citations
Scholar articles
F Jehan, S Sazawal, AH Baqui, MI Nisar, U Dhingra… - JAMA network open, 2020