Authors
Frederick CW Wu, Abdelouahid Tajar, Stephen R Pye, Alan J Silman, Joseph D Finn, Terence W O'Neill, Gyorgy Bartfai, Felipe Casanueva, Gianni Forti, Aleksander Giwercman, Ilpo T Huhtaniemi, Krzysztof Kula, Margus Punab, Steven Boonen, Dirk Vanderschueren, European Male Aging Study Group
Publication date
2008/7/1
Journal
The Journal of Clinical Endocrinology & Metabolism
Volume
93
Issue
7
Pages
2737-2745
Publisher
Oxford University Press
Description
Context: The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear.
Objective: The objective of the study was to investigate the relationships between lifestyle and health with reproductive hormones in aging men.
Design: This was a baseline cross-sectional survey on 3200 community-dwelling men aged 40–79 yr from a prospective cohort study in eight European countries.
Results: Four predictors were associated with distinct modes of altered function: 1) age: lower free T (FT; −3.12 pmol/liter·yr, P < 0.001) with raised LH, suggesting impaired testicular function; 2) obesity: lower total T (TT; −2.32 nmol/liter) and FT (−17.60 pmol/liter) for body mass index (BMI; ≥ 25 to < 30 kg/m2) and lower TT (−5.09 nmol/liter) and FT (−53.72 pmol/liter) for BMI 30 kg/m2 or greater (P < 0.001–0.01, referent: BMI < 25 kg/m2) with unchanged …
Total citations
Scholar articles
FCW Wu, A Tajar, SR Pye, AJ Silman, JD Finn… - The Journal of Clinical Endocrinology & Metabolism, 2008