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The photoinstability of plasmonic particles remains one remarkable obstacle before their clinical penetration as powerful contrast agents, for instance, in photoacoustic imaging. In particular, gold nanorods easily revert to nanospheres and so lose their best optical features under exposure to few-nanoseconds-long laser pulses. While this issue is attracting much attention and stimulating ad hoc solutions, such as the addition of rigid shells, the biological environment may cause even more instability. For instance, a frequent outcome of the interaction between this type of particles and malignant or immune cells is their tight confinement into endocytic vesicles. In this study, we assess whether this configuration may make an adverse impact on the photostability of gold nanorods, due to the effect of heat confinement. We compare experimental measurements from a limited set of representative samples and verify their …