Authors
Scott Ayton, Peng Lei, Dominic J Hare, James A Duce, Jessica L George, Paul A Adlard, Catriona McLean, Jack T Rogers, Robert A Cherny, David I Finkelstein, Ashley I Bush
Publication date
2015/2/25
Journal
Journal of Neuroscience
Volume
35
Issue
8
Pages
3591-3597
Publisher
Society for Neuroscience
Description
Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson's disease (PD) pathogenesis. We reported previously that the Alzheimer-associated β-amyloid precursor protein (APP) facilitates neuronal iron export. Here we report markedly decreased APP expression in dopaminergic neurons of human PD nigra and that APP−/− mice develop iron-dependent nigral cell loss. Conversely, APP-overexpressing mice are protected in the MPTP PD model. NO suppresses APP translation in mouse MPTP models, explaining how elevated NO causes iron-dependent neurodegeneration in PD.
Scholar articles
S Ayton, P Lei, DJ Hare, JA Duce, JL George… - Journal of Neuroscience, 2015