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A method for synthesizing representative weather data for future climate out of regional climate models (RCMs) was introduced previously for the energy simulation of buildings (Nik, 2016). The method suggests creating one typical and two extreme data sets based on the distribution of the outdoor dry bulb temperature (T_drybulb). This article extends the application of such weather data in the hygrothermal simulation of buildings by simulating a pre-fabricated wooden frame wall. To investigate the importance of considering moisture and rain conditions in creating the representative weather files, two more groups of weather data are synthesized based on the distribution of the equivalent temperature (T_equivalent) and rain. Moisture content, relative humidity, temperature and mould growth rate are calculated in the façade and insulation layers of the wall for several weather data sets. Results show that the synthesized …