Authors
Gwenaël GR Leday, Petra E Vértes, Sylvia Richardson, Jonathan R Greene, Tim Regan, Shahid Khan, Robbie Henderson, Tom C Freeman, Carmine M Pariante, Neil A Harrison, Edward Bullmore, Petra Vertes, Rudolf Cardinal, Gwenael Leday, Tom Freeman, David Hume, Zhaozong Wu, Carmine Pariante, Annamaria Cattaneo, Patricia Zunszain, Alessandra Borsini, Robert Stewart, David Chandran, Livia Carvalho, Joshua Bell, Luis Souza-Teodoro, Hugh Perry, Neil Harrison, Wayne Drevets, Gayle Wittenberg, Declan Jones, Annie Stylianou, V Hugh Perry, Wayne C Drevets, Gayle M Wittenberg, Edward T Bullmore
Publication date
2018/1/1
Journal
Biological psychiatry
Volume
83
Issue
1
Pages
70-80
Publisher
Elsevier
Description
Background
Peripheral inflammation is often associated with major depressive disorder (MDD), and immunological biomarkers of depression remain a focus of investigation.
Methods
We used microarray data on whole blood from two independent case-control studies of MDD: the GlaxoSmithKline–High-Throughput Disease-specific target Identification Program [GSK-HiTDiP] study (113 patients and 57 healthy control subjects) and the Janssen–Brain Resource Company study (94 patients and 100 control subjects). Genome-wide differential gene expression analysis (18,863 probes) resulted in a p value for each gene in each study. A Bayesian method identified the largest p-value threshold (q = .025) associated with twice the number of genes differentially expressed in both studies compared with the number of coincidental case-control differences expected by chance.
Results
A total of 165 genes were differentially …
Scholar articles
GGR Leday, PE Vértes, S Richardson, JR Greene… - Biological psychiatry, 2018