Authors
Hesham Abdelhady, Marwa Abdelrazik, Zakee Abdi, David Abdo, Amina Abdulle, Lynn Abel, Shrefee Abouzeenni, Gail Abrahamson, Yousuf Abusamra, Lisa Adams, Olumide Adebambo, Debo Ademokun, Neill Adhikari, Dominic Affron, Anu Aggarwal, Ronan Agno, Humayun Ahmad, Norfaizan Ahmad, Sophia Ahmed, Kate Ainscough, James Ainsworth, Giulia Airoldi, Lindianne Aitken, Francis Ajeneye, Naim Akhtar, Olajide Akinwumiju, Manaf Al-Bayati, Martin Albert, Meera Alderman, Ana Alegria, Brian Alexander, Peter DG Alexander, Jordan Alfonso, Hoodo Ali, Sabira Ali, Allameddine Allameddine, Sheila Allan, Isabelle Allard, Barbara Allen, Beverley Allen, Jess Allen, Laura Allen, Louise Allen, Suzanne Allibone, Richard Ambrosino, Kenneth Amenyah, Mariam Ammoun, Rekha Anand, Sai Priya Anand, Kristen Andersen, Corinne Anderson, Kevin Anderson, Thomas Anderson, Mark Andreae, Susan Andrews, Gregory Andrikopoulos, Aisha Anjum, Matthew Anstey, Micheline Antar, David Antcliffe, Pierre Antoine, Vikram Anumakonda, George Apostolides, Latha Aravindan, Gill Arbane, Emily Arbon, Simon Archer, Noah Aref, Ana-Marie Arias, Chantal Armali, Joel Armer-Ducker, Michelle Armstrong, Sylvia Armstrong-Fisher, John Arnold, Sarah Arnott, Andrea Arroyo, Valérie Arsenault, Diptesh Aryal, Adeeba Asghar, Glen Ashby, Deborah Asher, Ben Ashford, Suhail Ashgar, Murtaza Asif Ali, Angelique Aspinwall, Abigail Asquith, Tanya Atallah, Richard Athay-Hunt, Udara Attanayaka, Rita Atugonza, Michelle Aube, Marie-Christine Auclair, Karen Austin, Pauline Austin, Sidra Awan, Gina Bacon, Harleen Badhesha, Kavitha Bagavathy, Dawn Baglole, Clariza Bagnas, Catherine Bagot, Sean Bagshaw, Nadia Baig, Stephen Bailey, Kenneth Baillie, William Bain, Sanchia Baines, Aimi Baird, Charles Baker, Evelyn Baker, Penny Bakhtiari, Dhanalakshmi Bakthavatsalam, Morteza Balaie, Gagan Bali, Sonya Balkee, Amy Ballinger, Amy Bamford, Peter Bamford, Millie Banerjee, Lauren Banks, Jonathan Bannard-Smith, Nancy Banning, Bharat Bansal, Robert Banthorpe, Ian Barbash, Alex Barber, Russell Barber, Miriam Barbosa, Mercedes Barillas, Ryan Bariola, Gareth Barker, Nicky Barnes, Matthew Barnett, Nathaly Barnett, Rebecca Baron, Robert Bart, Jazz Bartholomew, Shauna Bartley, David Barton, Jan Barwell, Archana Bashyal, Kim Basile, Frances Bass, Christopher Bassford, Pavinder Bassi, Betsy Bassis, Ian Bateman, Michelle Bates, Samantha Bates, Donna Batty
Publication date
2021/11/2
Journal
Jama
Volume
326
Issue
17
Pages
1690-1702
Publisher
American Medical Association
Description
Importance
The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.
Objective
To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.
Design, Setting, and Participants
The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and January 18, 2021, within at least 1 domain; 2011 critically ill adults were randomized to open-label interventions in the immunoglobulin domain at 129 sites in 4 countries. Follow-up ended on April 19, 2021.
Interventions
The immunoglobulin domain randomized participants to receive 2 units of high-titer, ABO-compatible convalescent plasma (total volume of 550 mL ± 150 mL) within 48 hours of randomization (n = 1084 …
Scholar articles
H Abdelhady, M Abdelrazik, Z Abdi, D Abdo, A Abdulle… - Jama, 2021