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Burn injury which itself is a life-threatening event is associated with high mortality and morbidity due to associated burn wound infection (BWI). Thermal destruction of the skin barrier and concomitant depression of local and systemic host cellular and humoral immune responses are pivotal factors contributing to infectious complications in patients with severe burns. In burns involving more than 40% of the total body surface area (TBSA) almost 75% of all deaths are either due to sepsis from burn wound infection or infection related complications and/or inhalation injury. The survival rates for burn patients have however improved substantially in the past few decades due to advances in modern medical care in specialized burn centers. Improved outcomes for severely burned patients have been attributed to medical advances in fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection …