Authors
J Stephen Dumler, Kyoung-Seong Choi, Jose Carlos Garcia-Garcia, Nicole S Barat, Diana G Scorpio, Justin W Garyu, Dennis J Grab, Johan S Bakken
Publication date
2005/12
Source
Emerging infectious diseases
Volume
11
Issue
12
Pages
1828
Publisher
Centers for Disease Control and Prevention
Description
Human granulocytic anaplasmosis is a tickborne rickettsial infection of neutrophils caused by Anaplasma phagocytophilum. The human disease was first identified in 1990, although the pathogen was defined as a veterinary agent in 1932. Since 1990, US cases have markedly increased, and infections are now recognized in Europe. A high international seroprevalence suggests infection is widespread but unrecognized. The niche for A. phagocytophilum, the neutrophil, indicates that the pathogen has unique adaptations and pathogenetic mechanisms. Intensive study has demonstrated interactions with host-cell signal transduction and possibly eukaryotic transcription. This interaction leads to permutations of neutrophil function and could permit immunopathologic changes, severe disease, and opportunistic infections. More study is needed to define the immunology and pathogenetic mechanisms and to understand …
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Scholar articles
JS Dumler, KS Choi, JC Garcia-Garcia, NS Barat… - Emerging infectious diseases, 2005