Authors
Sukma Oktavianthi, Hidayat Trimarsanto, Clarissa A Febinia, Ketut Suastika, Made R Saraswati, Pande Dwipayana, Wibowo Arindrarto, Herawati Sudoyo, Safarina G Malik
Publication date
2012/12
Journal
Cardiovascular diabetology
Volume
11
Pages
1-10
Publisher
BioMed Central
Description
Background
Uncoupling protein 2 (UCP2) gene polymorphisms have been reported as genetic risk factors for obesity and type 2 diabetes mellitus (T2DM). We examined the association of commonly observed UCP2 G(−866)A (rs659366) and Ala55Val (C > T) (rs660339) single nucleotide polymorphisms (SNPs) with obesity, high fasting plasma glucose, and serum lipids in a Balinese population.
Methods
A total of 603 participants (278 urban and 325 rural subjects) were recruited from Bali Island, Indonesia. Fasting plasma glucose (FPG), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) were measured. Obesity was determined based on WHO classifications for adult Asians. Participants were genotyped for G(−866)A and Ala55Val polymorphisms of the UCP2 gene …
Total citations
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Scholar articles
S Oktavianthi, H Trimarsanto, CA Febinia, K Suastika… - Cardiovascular diabetology, 2012