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This paper charts the rapid rise of data science methodologies in manuscripts published in top journals for third sector scholarship, indicating their growing importance to research in the field. We draw on critical quantitative theory (QuantCrit) to challenge the assumed neutrality of data science insights that are especially prone to misrepresentation and unbalanced treatment of sub-groups (i.e., those marginalized and minoritized because of their race, gender, etc.). We summarize a set of challenges that result in biases within machine learning methods that are increasingly deployed in scientific inquiry. As a means of proactively addressing these concerns, we introduce the “Wells-Du Bois Protocol,” a tool that scholars can use to determine if their research achieves a baseline level of bias mitigation. Ultimately, this work aims to facilitate the diffusion of key insights from the field of QuantCrit by showing how new …