Authors
Sudha Seshadri, Annette L Fitzpatrick, M Arfan Ikram, Anita L DeStefano, Vilmundur Gudnason, Merce Boada, Joshua C Bis, Albert V Smith, Minerva M Carrasquillo, Jean Charles Lambert, Denise Harold, Elisabeth MC Schrijvers, Reposo Ramirez-Lorca, Stephanie Debette, WT Longstreth, A Cecile JW Janssens, V Shane Pankratz, Jean François Dartigues, Paul Hollingworth, Thor Aspelund, Isabel Hernandez, Alexa Beiser, Lewis H Kuller, Peter J Koudstaal, Dennis W Dickson, Christophe Tzourio, Richard Abraham, Carmen Antunez, Yangchun Du, Jerome I Rotter, Yurii S Aulchenko, Tamara B Harris, Ronald C Petersen, Claudine Berr, Michael J Owen, Jesus Lopez-Arrieta, Badri N Vardarajan, James T Becker, Fernando Rivadeneira, Michael A Nalls, Neill R Graff-Radford, Dominique Campion, Sanford Auerbach, Kenneth Rice, Albert Hofman, Palmi V Jonsson, Helena Schmidt, Mark Lathrop, Thomas H Mosley, Rhoda Au, Bruce M Psaty, Andre G Uitterlinden, Lindsay A Farrer, Thomas Lumley, Agustin Ruiz, Julie Williams, Philippe Amouyel, Steve G Younkin, Philip A Wolf, Lenore J Launer, Oscar L Lopez, Cornelia M Van Duijn, Monique MB Breteler
Publication date
2010/5/12
Journal
Jama
Volume
303
Issue
18
Pages
1832-1840
Publisher
American Medical Association
Description
Context
Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD).
Objectives
To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously published GWAS on more than 35 000 persons (8371 AD cases).
Design, Setting, and Participants
In stage 1, we identified strong genetic associations (P < 10−3) in a sample of 3006 AD cases and 14 642 controls by combining new data from the population-based Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (1367 AD cases [973 incident]) with previously reported results from the Translational Genomics Research Institute and the Mayo AD GWAS. We identified 2708 single-nucleotide …
Total citations
Scholar articles
S Seshadri, AL Fitzpatrick, MA Ikram, AL DeStefano… - Jama, 2010