Authors
Lindsay A Farrer, L Adrienne Cupples, Jonathan L Haines, Bradley Hyman, Walter A Kukull, Richard Mayeux, Richard H Myers, Margaret A Pericak-Vance, Neil Risch, Cornelia M Van Duijn
Publication date
1997/10/22
Journal
Jama
Volume
278
Issue
16
Pages
1349-1356
Publisher
American Medical Association
Description
Objective
—To examine more closely the association between apolipoprotein E (APOE) genotype and Alzheimer disease (AD) by age and sex in populations of various ethnic and racial denominations.
Data Sources
—Forty research teams contributed data onAPOEgenotype, sex, age at disease onset, and ethnic background for 5930 patients who met criteria for probable or definite AD and 8607 controls without dementia who were recruited from clinical, community, and brain bank sources.
Main Outcome Measures
—Odds ratios (ORs) and 95% confidence intervals (Cls) for AD, adjusted for age and study and stratified by major ethnic group (Caucasian, African American, Hispanic, and Japanese) and source, were computed forAPOEgenotypes ∈2/∈2,∈2/∈3,∈2/∈4,∈3/∈4 and ∈4/∈4 relative to the ∈3/∈3 group. The influence of age and sex on the OR for each genotype was assessed using logistic regression …
Total citations
Scholar articles
LA Farrer, LA Cupples, JL Haines, B Hyman, WA Kukull… - Jama, 1997
LA Farrer, LA Cupples, JL Haines, B Hyman, WA Kukull… - Jama, 1997
Effects of age, gender and ethnicity on the association between APOE genotype and Alzheimer disease.*
LA Farrer, LA Cupples, J Haines, B Hyman, W Kukull… - American Journal of Human Genetics, 1997