Authors
Oguzhan Alagoz, Lisa M Maillart, Andrew J Schaefer, Mark S Roberts
Publication date
2007/11
Journal
Management Science
Volume
53
Issue
11
Pages
1702-1715
Publisher
INFORMS
Description
The only therapy for a patient with end-stage liver disease (ESLD) is liver transplantation, which is performed by using either a cadaveric liver from a deceased donor or a portion of a living-donor's liver. This study addresses the following decision problem for an ESLD patient with an available living donor. Should she have a transplantation now or wait? If she decides to have the transplantation now, should she use her living-donor liver or a cadaveric liver for transplantation? We formulate this problem as a discrete-time, infinite-horizon Markov decision process model and solve it using clinical data. Because living donors are typically related to the recipient, we incorporate a disutility associated with using the living-donor liver as opposed to using a cadaveric liver. We perform a structural analysis of the model, including a set of intuitive conditions that ensure the existence of structured policies such as an at-most …
Total citations
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Scholar articles
O Alagoz, LM Maillart, AJ Schaefer, MS Roberts - Management Science, 2007