Authors
Nicholas F Parrish, Feng Gao, Hui Li, Elena E Giorgi, Hannah J Barbian, Erica H Parrish, Lara Zajic, Shilpa S Iyer, Julie M Decker, Amit Kumar, Bhavna Hora, Anna Berg, Fangping Cai, Jennifer Hopper, Thomas N Denny, Haitao Ding, Christina Ochsenbauer, John C Kappes, Rachel P Galimidi, Anthony P West Jr, Pamela J Bjorkman, Craig B Wilen, Robert W Doms, Meagan O’Brien, Nina Bhardwaj, Persephone Borrow, Barton F Haynes, Mark Muldoon, James P Theiler, Bette Korber, George M Shaw, Beatrice H Hahn
Publication date
2013/4/23
Journal
Proceedings of the National Academy of Sciences
Volume
110
Issue
17
Pages
6626-6633
Publisher
National Academy of Sciences
Description
Defining the virus–host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous analyses have failed to identify phenotypic properties other than chemokine receptor 5 (CCR5) and CD4+ T-cell tropism that are preferentially associated with viral transmission. However, most of these studies were limited to examining envelope (Env) function in the context of pseudoviruses. Here, we generated infectious molecular clones of transmitted founder (TF; n = 27) and chronic control (CC; n = 14) viruses of subtypes B (n = 18) and C (n = 23) and compared their phenotypic properties in assays specifically designed to probe the earliest stages of HIV-1 infection. We found that TF virions were 1.7-fold more infectious (P = 0.049) and contained 1.9-fold more Env per particle (P = 0.048 …
Scholar articles
NF Parrish, F Gao, H Li, EE Giorgi, HJ Barbian… - Proceedings of the National Academy of Sciences, 2013