Authors
Lina A Knudsen, Line SF Zachariassen, Mikael L Strube, Jesper F Havelund, Bartosz Pilecki, Anders B Nexoe, Frederik T Møller, Signe B Sørensen, Niels Marcussen, Nils J Færgeman, Andre Franke, Corinna Bang, Uffe Holmskov, Axel K Hansen, Vibeke Andersen
Publication date
2024/4/1
Journal
Comparative Medicine
Volume
74
Issue
2
Pages
55-69
Publisher
American Association for Laboratory Animal Science
Description
Disturbances in gut microbiota are prevalent in inflammatory bowel disease (IBD), which includes ulcerative colitis (UC). However, whether these disturbances contribute to development of the disease or are a result of the disease is unclear. In pairs of human twins discordant for IBD, the healthy twin has a higher risk of developing IBD and a gut microbiota that is more similar to that of IBD patients as compared with healthy individuals. Furthermore, appropriate medical treatment may mitigate these disturbances. To study the correlation between microbiota and IBD, we transferred stool samples from a discordant human twin pair: one twin being healthy and the other receiving treatment for UC. The stool samples were transferred from the disease-discordant twins to germ-free pregnant dams. Colitis was induced in the offspring using dextran sodium sulfate. As compared with offspring born to mice dams inoculated …