Authors
Liesbeth Tytgat, Marica Markovic, Taimoor H Qazi, Maxime Vagenende, Fabrice Bray, José C Martins, Christian Rolando, Hugo Thienpont, Heidi Ottevaere, Aleksandr Ovsianikov, Peter Dubruel, Sandra Van Vlierberghe
Publication date
2019
Journal
Journal of Materials Chemistry B
Volume
7
Issue
19
Pages
3100-3108
Publisher
Royal Society of Chemistry
Description
Gelatin is frequently used in various biomedical applications. However, gelatin is generally extracted from an animal source, which can result in issues with reproducibility as well as pathogen transmittance. Therefore, we have investigated the potential of a recombinant peptide based on collagen I (RCPhC1) for tissue engineering applications and more specifically for adipose tissue regeneration. In the current paper, RCPhC1 was functionalized with photo-crosslinkable methacrylamide moieties to enable subsequent UV-induced crosslinking in the presence of a photo-initiator. The resulting biomaterial (RCPhC1-MA) was characterized by evaluating the crosslinking behaviour, the mechanical properties, the gel fraction, the swelling properties and the biocompatibility. The obtained results were compared with the data obtained for methacrylamide-modified gelatin (Gel-MA). The results indicated that the properties of …
Total citations
202020212022202320246101983
Scholar articles
L Tytgat, M Markovic, TH Qazi, M Vagenende, F Bray… - Journal of Materials Chemistry B, 2019