Authors
David Amar, Nicole R Gay, David Jimenez-Morales, Pierre M Jean Beltran, Megan E Ramaker, Archana Natarajan Raja, Bingqing Zhao, Yifei Sun, Shruti Marwaha, David A Gaul, Steven G Hershman, Alexis Ferrasse, Ashley Xia, Ian Lanza, Facundo M Fernández, Stephen B Montgomery, Andrea L Hevener, Euan A Ashley, Martin J Walsh, Lauren M Sparks, Charles F Burant, R Scott Rector, John Thyfault, Matthew T Wheeler, Bret H Goodpaster, Paul M Coen, Simon Schenk, Sue C Bodine, Malene E Lindholm, Joshua N Adkins, Jose Juan Almagro Armenteros, Mary Anne S Amper, Dam Bae, Marcas Bamman, Nasim Bararpour, Jerry Barnes, Bryan C Bergman, Daniel H Bessesen, Nicholas T Broskey, Thomas W Buford, Steven Carr, Toby L Chambers, Clarisa Chavez, Roxanne Chiu, Natalie Clark, Gary Cutter, Charles R Evans, Edziu Franczak, Nicole Gagne, Yongchao Ge, Krista M Hennig, Joseph A Houmard, Kim M Huffman, Chia-Jui Hung, Chelsea Hutchinson-Bunch, Olga Ilkayeva, Bailey E Jackson, Catherine M Jankowski, Christopher A Jin, Neil M Johannsen, Daniel H Katz, Hasmik Keshishian, Wendy M Kohrt, Kyle S Kramer, William E Kraus, Bridget Lester, Jun Z Li, Ana K Lira, Adam Lowe, DR Mani, Gina M Many, Sandy May, Edward L Melanson, Samuel G Moore, Kerrie L Moreau, Nicolas Musi, Daniel Nachun, Venugopalan D Nair, Christopher Newgard, German Nudelman, Paul D Piehowski, Hanna Pincas, Wei-Jun Qian, Tuomo Rankinen, Blake B Rasmussen, Eric Ravussin, Jessica L Rooney, Scott Rushing, Mihir Samdarshi, James A Sanford, Irene E Schauer, Stuart C Sealfon, Kevin S Smith, Gregory R Smith, Michael Snyder, Cynthia L Stowe, Jennifer W Talton, Christopher Teng, Anna Thalacker-Mercer, Russell Tracy, Scott Trappe, Todd A Trappe, Mital Vasoya, Nikolai G Vetr, Elena Volpi, Michael P Walkup, Laurens Wiel, Si Wu, Zhen Yan, Jiye Yu, Elena Zaslavsky, Navid Zebarjadi, Jimmy Zhen
Publication date
2024/4/15
Journal
Cell Metabolism
Publisher
Elsevier
Description
Mitochondria have diverse functions critical to whole-body metabolic homeostasis. Endurance training alters mitochondrial activity, but systematic characterization of these adaptations is lacking. Here, the Molecular Transducers of Physical Activity Consortium mapped the temporal, multi-omic changes in mitochondrial analytes across 19 tissues in male and female rats trained for 1, 2, 4, or 8 weeks. Training elicited substantial changes in the adrenal gland, brown adipose, colon, heart, and skeletal muscle. The colon showed non-linear response dynamics, whereas mitochondrial pathways were downregulated in brown adipose and adrenal tissues. Protein acetylation increased in the liver, with a shift in lipid metabolism, whereas oxidative proteins increased in striated muscles. Exercise-upregulated networks were downregulated in human diabetes and cirrhosis. Knockdown of the central network protein 17-beta …
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Scholar articles
D Amar, NR Gay, D Jimenez-Morales, PMJ Beltran… - Cell Metabolism, 2024