Authors
Daniel J Panyard, Lianne M Reus, Muhammad Ali, Jihua Liu, Yuetiva K Deming, Qiongshi Lu, Gwendlyn Kollmorgen, Margherita Carboni, Norbert Wild, Pieter J Visser, Lars Bertram, Henrik Zetterberg, Kaj Blennow, Johan Gobom, Dan Western, Yun Ju Sung, Cynthia M Carlsson, Sterling C Johnson, Sanjay Asthana, Carlos Cruchaga, Betty M Tijms, Corinne D Engelman, Michael P Snyder
Publication date
2024/5/29
Journal
Alzheimer's & Dementia
Description
INTRODUCTION
Recent genome‐wide association studies (GWAS) have reported a genetic association with Alzheimer's disease (AD) at the TNIP1/GPX3 locus, but the mechanism is unclear.
METHODS
We used cerebrospinal fluid (CSF) proteomics data to test (n = 137) and replicate (n = 446) the association of glutathione peroxidase 3 (GPX3) with CSF biomarkers (including amyloid and tau) and the GWAS‐implicated variants (rs34294852 and rs871269).
RESULTS
CSF GPX3 levels decreased with amyloid and tau positivity (analysis of variance P = 1.5 × 10−5) and higher CSF phosphorylated tau (p‐tau) levels (P = 9.28 × 10−7). The rs34294852 minor allele was associated with decreased GPX3 (P = 0.041). The replication cohort found associations of GPX3 with amyloid and tau positivity (P = 2.56 × 10−6) and CSF p‐tau levels (P = 4.38 × 10−9).
DISCUSSION
These results suggest variants in the TNIP1 …
Scholar articles
DJ Panyard, LM Reus, M Ali, J Liu, YK Deming, Q Lu… - Alzheimer's & Dementia, 2024