Authors
Management Group Liefer Laura A. 51 Wetterstrand Kris A. 51 Good Peter J. 51 Feingold Elise A. 51 Guyer Mark S. 51 Collins Francis S. 52, Baylor College of Medicine Human Genome Sequencing Center*, Washington University Genome Sequencing Center*, Broad Institute*, Children’s Hospital Oakland Research Institute*, Mark Gerstein, Stylianos E Antonarakis, Serafim Batzoglou, Nick Goldman, Ross C Hardison, David Haussler, Webb Miller, Lior Pachter, Eric D Green, Arend Sidow, Zhiping Weng, Nathan D Trinklein, Yutao Fu, Zhengdong D Zhang, Ulaş Karaöz, Leah Barrera, Rhona Stuart, Deyou Zheng, Srinka Ghosh, Paul Flicek, David C King, James Taylor, Adam Ameur, Stefan Enroth, Mark C Bieda, Christoph M Koch, Heather A Hirsch, Chia-Lin Wei, Jill Cheng, Jonghwan Kim, Akshay A Bhinge, Paul G Giresi, Nan Jiang, Jun Liu, Fei Yao, Wing-Kin Sung, Kuo Ping Chiu, Vinsensius B Vega, Charlie WH Lee, Patrick Ng, Atif Shahab, Edward A Sekinger, Annie Yang, Zarmik Moqtaderi, Zhou Zhu, Xiaoqin Xu, Sharon Squazzo, Matthew J Oberley, David Inman, Michael A Singer, Todd A Richmond, Kyle J Munn, Alvaro Rada-Iglesias, Ola Wallerman, Jan Komorowski, Gayle K Clelland, Sarah Wilcox, Shane C Dillon, Robert M Andrews, Joanna C Fowler, Phillippe Couttet, Keith D James, Gregory C Lefebvre, Alexander W Bruce, Oliver M Dovey, Peter D Ellis, Pawandeep Dhami, Cordelia F Langford, Nigel P Carter, David Vetrie, Philipp Kapranov, David A Nix, Ian Bell, Sandeep Patel, Joel Rozowsky, Ghia Euskirchen, Stephen Hartman, Jin Lian, Jiaqian Wu, Alexander E Urban, Peter Kraus, Sara Van Calcar, Nate Heintzman, Tae Hoon Kim, Kun Wang, Chunxu Qu, Gary Hon, Rosa Luna, Christopher K Glass, M Geoff Rosenfeld, Shelley Force Aldred, Sara J Cooper, Anason Halees, Jane M Lin, Hennady P Shulha, Xiaoling Zhang, Mousheng Xu, Jaafar NS Haidar, Yong Yu, Ewan Birney*, Sherman Weissman, Yijun Ruan, Jason D Lieb, Vishwanath R Iyer, Roland D Green, Thomas R Gingeras, Claes Wadelius, Ian Dunham, Kevin Struhl, Ross C Hardison, Mark Gerstein, Peggy J Farnham, Richard M Myers, Bing Ren, Michael Snyder, Daryl J Thomas, Kate Rosenbloom, Rachel A Harte, Angie S Hinrichs, Heather Trumbower, Hiram Clawson, Jennifer Hillman-Jackson, Ann S Zweig, Kayla Smith, Archana Thakkapallayil, Galt Barber, Robert M Kuhn, Donna Karolchik, David Haussler, W James Kent, Emmanouil T Dermitzakis, Lluis Armengol, Christine P Bird, Taane G Clark, Gregory M Cooper, Paul IW de Bakker, Andrew D Kern, Nuria Lopez-Bigas, Joel D Martin, Barbara E Stranger
Publication date
2007/6/14
Journal
nature
Volume
447
Issue
7146
Pages
799-816
Publisher
Nature Publishing Group UK
Description
We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a …
Total citations
Scholar articles
Management Group Liefer Laura A. 51 Wetterstrand … - nature, 2007
E Birney, JA Stamatoyannopoulos, A Dutta, R Guigó… - Nature, 2007
ENCODE Project Consortium - Nature, 2007
ES BIRNEY, JA Stamatoyannopoulos - NATURE. UK. McGraw Hill, 2007