Authors
Eugene Sobngwi, Andre-Pascal Kengne, Justin B Echouffo-Tcheugui, Simeon Choukem, Joelle Sobngwi-Tambekou, Eric V Balti, Mark S Pearce, Valentin Siaha, Aissa S Mamdjokam, Valery Effoe, Eric Lontchi-Yimagou, Oliver T Donfack, Barbara Atogho-Tiedeu, Philippe Boudou, Jean-Francois Gautier, Jean-Claude Mbanya
Publication date
2014/12
Journal
BMC Endocrine Disorders
Volume
14
Pages
1-10
Publisher
BioMed Central
Description
Background
We aimed to evaluate the predictive utility of common fasting insulin sensitivity indices, and non-laboratory surrogates [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)] in sub-Saharan Africans without diabetes.
Methods
We measured fasting glucose and insulin, and glucose uptake during 80/mU/m2/min euglycemic clamp in 87 Cameroonians (51 men) aged (SD) 34.6 (11.4) years. We derived insulin sensitivity indices including HOMA-IR, quantitative insulin sensitivity check index (QUICKI), fasting insulin resistance index (FIRI) and glucose-to-insulin ratio (GIR). Indices and clinical predictors were compared to clamp using correlation tests, robust linear regressions and agreement of classification by sex-specific thirds.
Results
The mean insulin sensitivity was M = 10.5 ± 3.2 mg/kg/min …
Scholar articles
E Sobngwi, AP Kengne, JB Echouffo-Tcheugui… - BMC Endocrine Disorders, 2014