Authors
Joshua J Joseph, Justin B Echouffo-Tcheugui, Rita R Kalyani, Hsin-Chieh Yeh, Alain G Bertoni, Valery S Effoe, Ramon Casanova, Mario Sims, Adolfo Correa, Wen-Chih Wu, Gary S Wand, Sherita H Golden
Publication date
2016/4/1
Journal
The Journal of Clinical Endocrinology & Metabolism
Volume
101
Issue
4
Pages
1770-1778
Publisher
Oxford University Press
Description
Context
Previous research has suggested that activation of the renin-angiotensin-aldosterone system may promote insulin resistance and β-cell dysfunction, but the association with incident diabetes in African Americans is unknown.
Objective
We examined the association of aldosterone and renin with insulin resistance, β-cell function, and incident diabetes in a large African American cohort.
Design
The Jackson Heart Study is a prospective study of the development and progression of cardiovascular disease in African Americans.
Setting
Participants were recruited from the tricounty area of metropolitan Jackson, Mississippi.
Participants
A total of 5301 African American adults, aged 21–94 years, were assessed at baseline and through 12 years of follow-up. Data on aldosterone, renin, and risk factors were …
Scholar articles
JJ Joseph, JB Echouffo-Tcheugui, RR Kalyani, HC Yeh… - The Journal of Clinical Endocrinology & Metabolism, 2016