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This work primarily concentrates on the design of fault‐tolerant anti‐disturbance control for synchronization of multiple memristor‐based neural networks subject to time delay, matched and mismatched disturbances. Moreover, in the addressed network model, we consider parameter uncertainties and actuator faults. Firstly in order to estimate the matched disturbances generated by the exogenous system, a disturbance observer is devised. Whereas, the mismatched part is tackled by employing the mixed ℋ∞$$ {\mathscr{H}}_{\infty } $$ and passivity performance indexes. Subsequently, a unified controller is designed by incorporating error feedback control and the disturbance estimate. Further, with the assistance of Lyapunov stability theory and linear matrix inequality technique, an adequate criteria is procured to ascertain the required synchronization criteria for the assayed network model with the mixed ℋ∞ …