Authors
Felicity Ng, Michael Berk, Olivia Dean, Ashley I Bush
Publication date
2008/9/1
Source
International Journal of Neuropsychopharmacology
Volume
11
Issue
6
Pages
851-876
Publisher
Cambridge University Press
Description
Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications. A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Previews, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid …
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Scholar articles
F Ng, M Berk, O Dean, AI Bush - International Journal of Neuropsychopharmacology, 2008