Authors
Mohamed I Madkour, Ahmed T El-Serafi, Haitham A Jahrami, Naglaa M Sherif, Rasha E Hassan, Samir Awadallah
Publication date
2019/9/1
Journal
diabetes research and clinical practice
Volume
155
Pages
107801
Publisher
Elsevier
Description
Aim
A growing body of evidence supports the impact of intermittent fasting on normalizing body metabolism and lowering oxidative stress and inflammation. Mounting evidence confirms that oxidative stress and chronic inflammation trigger the way for the development of metabolic diseases, such as diabetes. This research was conducted to evaluate the impact of Ramadan intermittent fasting (RIF) on the expression of cellular metabolism (SIRT1 and SIRT3) and antioxidant genes (TFAM, SOD2, and Nrf2).
Methods
Fifty-six (34 males and 22 females) overweight and obese subjects and six healthy body weight controls were recruited and monitored before and after Ramadan.
Results
Results showed that the relative gene expressions in obese subjects in comparison to counterpart expressions of controls for the antioxidant genes (TFAM, SOD2, and Nrf2) were significantly increased at the end of Ramadan, with percent …
Scholar articles
MI Madkour, AT El-Serafi, HA Jahrami, NM Sherif… - diabetes research and clinical practice, 2019