Authors
Daniel Zell, Svenja Warratz, Dmitri Gelman, Simon J Garden, Lutz Ackermann
Publication date
2016/1/22
Journal
Chemistry–A European Journal
Volume
22
Issue
4
Pages
1248-1252
Description
Well‐defined ruthenium(II) phosphinous acid (PA) complexes enabled chemo‐, site‐, and diastereoselective C−H functionalization of arenes and alkenes with ample scope. The outstanding catalytic activity was reflected by catalyst loadings as low as 0.75 mol %, and the most step‐economical access reported to date to angiotensin II receptor antagonist blockbuster drugs. Mechanistic studies indicated a kinetically relevant C−X cleavage by a single‐electron transfer (SET)‐type elementary process, and provided evidence for a PA‐assisted C−H ruthenation step.
Scholar articles
D Zell, S Warratz, D Gelman, SJ Garden, L Ackermann - Chemistry–A European Journal, 2016