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Conclusions

In summary, we have developed the first phosphine-enabled ruthenium-catalyzed C–H/C–F functionalization to furnish synthetically useful fluorinated ketones. Thus, the judicious choice of a tertiary phosphine ligand and a stoichiometric base set the stage for a switch in chemoselectivity from a common ruthenium-catalyzed C–H hydroarylation manifold to a challenging allylative C–H/C–F functionalization. The versatile ruthenium (II) catalyst was characterized by high levels of chemo-, position,