Authors
Robert Miranda Jr, Hayley Treloar, Alexander Blanchard, Alicia Justus, Peter M Monti, Thomas Chun, Robert Swift, Jennifer W Tidey, Chad J Gwaltney
Publication date
2017/5
Journal
Addiction Biology
Volume
22
Issue
3
Pages
779-790
Description
Cannabis misuse accounts for nearly all of the substance abuse treatment admissions among youth in the United States. Most youth do not experience sustained benefit from existing psychosocial treatments; however, medication development research for treating adolescent cannabis misuse is almost nonexistent. We conducted a double‐blind, placebo‐controlled, pilot study to test the potential efficacy of topiramate plus motivational enhancement therapy (MET) for treating cannabis use among adolescents. Sixty‐six heavy cannabis users, ages 15 to 24 years, were randomized to one of two 6‐week treatment conditions: topiramate plus MET or placebo plus MET. Topiramate was titrated over 4 weeks then stabilized at 200 mg/day for 2 weeks. MET was delivered biweekly for a total of three sessions. Only 48 percent of youths randomized to topiramate completed the 6‐week trial (n = 19), compared with 77 …
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