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In this chapter we set out the methods used in the economic evaluation of systematic screening strategies for AF. We begin by defining the decision question that our economic model addressed, the modelling approach taken and the outputs reported. We then present the results of a review of previous economic models evaluating population-based screening strategies for AF. This is followed by a description of the structure of our model and the inputs required to populate it. Next, we describe a supplementary literature review of observational studies that we used to identify evidence on the natural history of AF, to provide inputs to the model, and present the results from this review. We then summarise all of the evidence used for inputs to the model and describe the sensitivity analyses that we conducted.