Authors
Viola Vaccarino, Candace McClure, B Delia Johnson, David S Sheps, Vera Bittner, Thomas Rutledge, Leslee J Shaw, George Sopko, Marian B Olson, David S Krantz, Susmita Parashar, Oscar C Marroquin, C Noel Bairey Merz
Publication date
2008/1/1
Journal
Psychosomatic medicine
Volume
70
Issue
1
Pages
40-48
Publisher
LWW
Description
Background:
The relationship between depression and the metabolic syndrome is unclear, and whether metabolic syndrome explains the association between depression and cardiovascular disease (CVD) risk is unknown.
Methods:
We studied 652 women who received coronary angiography as part of the Women's Ischemia Syndrome Evaluation (WISE) study and completed the Beck Depression Inventory (BDI). Women who had both elevated depressive symptoms (BDI≥ 10) and a previous diagnosis of depression were considered at highest risk, whereas those with one of the two conditions represented an intermediate group. The metabolic syndrome was defined according to the ATP-III criteria. The main outcome was incidence of adverse CVD events (hospitalizations for myocardial infarction, stroke, congestive heart failure, and CVD-related mortality) over a median follow-up of 5.9 years.
Results:
After adjusting …
Total citations
Scholar articles
V Vaccarino, C McClure, BD Johnson, DS Sheps… - Psychosomatic medicine, 2008