Authors
Jeffrey A Sparks, Shun‐Chiao Chang, Katherine P Liao, Bing Lu, Alexander R Fine, Daniel H Solomon, Karen H Costenbader, Elizabeth W Karlson
Publication date
2016/6
Journal
Arthritis care & research
Volume
68
Issue
6
Pages
753-762
Description
Objective
To evaluate rheumatoid arthritis (RA) and mortality risk among women followed prospectively in the Nurses’ Health Study (NHS).
Methods
We analyzed 119,209 women in the NHS who reported no connective tissue disease at enrollment in 1976. Comorbidity and lifestyle data were collected through biennial questionnaires. Incident RA cases were validated by medical records review. Cause of death was determined by death certificate and medical records review. Cox regression models estimated hazard ratios (HRs) and 95% confidence intervals (95% CIs) for all‐cause, cardiovascular disease (CVD), cancer, and respiratory disease mortality for women with RA compared to those without RA.
Results
We validated 964 incident RA cases and identified 28,808 deaths during 36 years of prospective follow‐up. Of 307 deaths among women with RA, 80 (26%) were from cancer, 70 (23%) were from CVD …
Scholar articles
JA Sparks, SC Chang, KP Liao, B Lu, AR Fine… - Arthritis care & research, 2016
JA Sparks, SC Chang, KP Liao, B Lu, DH Solomon… - ARTHRITIS & RHEUMATOLOGY, 2014