Authors
Anthony V D'Amico, Richard Whittington, S Bruce Malkowicz, Delray Schultz, Kenneth Blank, Gregory A Broderick, John E Tomaszewski, Andrew A Renshaw, Irving Kaplan, Clair J Beard, Alan Wein
Publication date
1998/9/16
Journal
Jama
Volume
280
Issue
11
Pages
969-974
Publisher
American Medical Association
Description
Context
Interstitial radiation (implant) therapy is used to treat clinically localized adenocarcinoma of the prostate, but how it compares with other treatments is not known.
Objective
To estimate control of prostate-specific antigen (PSA) after radical prostatectomy (RP), external beam radiation (RT), or implant with or without neoadjuvant androgen deprivation therapy in patients with clinically localized prostate cancer.
Design
Retrospective cohort study of outcome data compared using Cox regression multivariable analyses.
Setting and Patients
A total of 1872 men treated between January 1989 and October 1997 with an RP (n=888) or implant with or without neoadjuvant androgen deprivation therapy (n=218) at the Hospital of the University of Pennsylvania, Philadelphia, or RT (n=766) at the Joint Center for Radiation Therapy, Boston, Mass, were enrolled.
Main Outcome Measure
Actuarial freedom from PSA failure …
Total citations
Scholar articles
AV D'Amico, R Whittington, SB Malkowicz, D Schultz… - Jama, 1998