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In the present investigation, the generalized operators of fractional integration involving Appell’s function F3 (.) due to Marichev-Saigo-Maeda are applied to the M-series and the Fox’s H-function. M-series is a further extension of both Mittag-Leffler function and generalized hypergeometric function pFq. Both H-function and M-series have recently found essential applications in solving problems in physics, biology, engineering and applied sciences. The results are expressed in terms of generalized Wright function and H-function.