Authors
Stephen G Henry, Shao-You Fang, Andrew J Crawford, Garen J Wintemute, Iraklis Erik Tseregounis, James J Gasper, Aaron Shev, Abigail R Cartus, Brandon DL Marshall, Daniel J Tancredi, Magdalena Cerdá, Susan L Stewart
Publication date
2024/2
Journal
Journal of General Internal Medicine
Volume
39
Issue
3
Pages
393-402
Publisher
Springer International Publishing
Description
Background
Both increases and decreases in patients’ prescribed daily opioid dose have been linked to increased overdose risk, but associations between 30-day dose trajectories and subsequent overdose risk have not been systematically examined.
Objective
To examine the associations between 30-day prescribed opioid dose trajectories and fatal opioid overdose risk during the subsequent 15 days.
Design
Statewide cohort study using linked prescription drug monitoring program and death certificate data. We constructed a multivariable Cox proportional hazards model that accounted for time-varying prescription-, prescriber-, and pharmacy-level factors.
Participants
All patients prescribed an opioid analgesic in California from March to December, 2013 (5,326,392 patients).
Main Measures
Dependent variable: fatal drug overdose involving opioids. Primary independent variable: a 16-level variable denoting all …
Total citations
Scholar articles
SG Henry, SY Fang, AJ Crawford, GJ Wintemute… - Journal of General Internal Medicine, 2024