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The emergence of a new generation of remote sensing and geopositioning technologies, as well as increased capabilities in image processing, computing, and inferential techniques, have enabled the development and implementation of increasingly efficient and cost-effective multilevel sampling designs for forest inventory. In this paper, we (i) describe the conceptual basis of multilevel sampling, (ii) provide a detailed review of several previously implemented multilevel inventory designs, (iii) describe several important technical considerations that can influence the efficiency of a multilevel sampling design, and (iv) demonstrate the application of a modern multilevel sampling approach for estimating the forest biomass resources in a remote area of interior Alaska. This approach utilized a combination of ground plots, lidar strip sampling, satellite imagery (multispectral and radar), and classified land cover …